Lactic acid yog koj tus phooj ywg, txawm li cas los xij koj tus kws qhia qoj ib ce

2024 Tus sau: Malcolm Clapton | [email protected]. Kawg hloov kho: 2023-12-17 03:58

Lactic acid tsis "acidify" cov leeg, tab sis ua rau kom muaj zog thiab tiv thaiv lub hlwb.

Dab tsi yog lactic acid thiab lactate

Peb lub cev tas li xav tau lub zog rau lub cev ua haujlwm thiab cov leeg nqaij. Carbohydrates nkag mus rau hauv lub cev nrog zaub mov. Hauv cov hnyuv, lawv tau tawg mus rau hauv cov piam thaj, uas tom qab ntawd nkag mus rau hauv cov hlab ntsha thiab thauj mus rau cov hlwb hauv lub cev, suav nrog cov leeg nqaij.

Hauv cytoplasm ntawm cov hlwb, glycolysis tshwm sim - oxidation ntawm qabzib rau pyruvate (pyruvic acid) nrog kev tsim ntawm ATP (adenosine triphosphate, lub ntsiab roj ntawm lub cev). Tom qab ntawd, vim yog cov enzyme lactate dehydrogenase, pyruvate txo qis rau lactic acid, uas tam sim ntawd poob ib hydrogen ion, tuaj yeem ntxiv sodium (Na +) lossis potassium (K +) ions thiab hloov mus rau hauv lactic acid ntsev - lactate.

Raws li koj tuaj yeem pom, lactic acid thiab lactate tsis yog tib yam. Nws accumulates nyob rau hauv cov leeg, nws yog lactate uas yog excreted thiab ua tiav. Yog li ntawd, nws tsis raug los tham txog lactic acid hauv cov leeg.

Txog xyoo 1970, lactate tau suav hais tias yog cov khoom lag luam uas tshwm sim hauv cov leeg ua haujlwm vim tsis muaj oxygen. Txawm li cas los xij, kev tshawb fawb hauv kaum xyoo tsis ntev los no tau tsis lees paub qhov kev thov no. Piv txwv li, Matthew J. Rogatzki hauv 2015 pom Lactate ib txwm yog qhov khoom kawg ntawm glycolysis, uas glycolysis ib txwm xaus nrog kev tsim lactate.

Qhov no kuj tau thov los ntawm George A. Brooks ntawm University of California, uas tau kawm lactic acid rau ntau tshaj 30 xyoo. Kev sib xyaw ntawm lactate tsuas yog qhia qhov sib npaug ntawm nws cov khoom tsim tawm thiab tshem tawm thiab tsis cuam tshuam rau aerobic lossis anaerobic metabolism.

Lactate yog ib txwm tsim thaum lub sij hawm glycolysis, tsis hais seb puas muaj lossis tsis muaj oxygen. Nws yog tsim txawm tias thaum so.

Vim li cas coob tus neeg tsis nyiam lactic acid

Lus dab neeg 1. Lactic acid ua rau mob nqaij

Cov lus dab neeg no tau ntev dhau los tsis pom zoo, tab sis qee tus kws qhia qoj ib ce tseem liam tias lactate rau cov leeg mob, lossis mob qeeb. Qhov tseeb, qib lactate poob qis hauv feeb tom qab koj tso tseg kev tawm dag zog thiab rov qab tag nrho txog ib teev tom qab kev tawm dag zog.

Yog li, lactate tsis tuaj yeem ua rau mob nqaij 24-72 teev tom qab kev tawm dag zog. Koj tuaj yeem nyeem txog dab tsi mechanisms ua rau koj cov leeg mob tom qab kev cob qhia hauv kab lus no.

Lus dab neeg 2. Lactic acid "acidifies" cov leeg thiab ua rau lawv qaug zog

Muaj kev ntseeg dav dav tias cov ntshav lactate muaj feem cuam tshuam rau cov leeg nqaij. Txawm li cas los xij, qhov tseeb, lactate tsis yog liam rau qhov no, tab sis hydrogen ions, uas ua rau cov acidity ntawm cov ntaub so ntswg. Thaum cov pH sib npaug hloov mus rau sab acidic, acidosis tshwm sim. Muaj ntau txoj kev tshawb fawb qhia tias acidosis tsis zoo cuam tshuam rau cov leeg nqaij.

Cov kab lus tshawb fawb Biochemistry ntawm kev tawm dag zog ua rau cov metabolism hauv acidosis los ntawm Robert A. Robergs hais tias hydrogen ions raug tso tawm txhua zaus ATP tawg mus rau ADP (adenosine diphosphate) thiab inorganic phosphate nrog lub zog tso tawm …

Thaum koj ua haujlwm ntawm qhov nruab nrab siv, hydrogen ions yog siv los ntawm mitochondria rau oxidative phosphorylation (txo ntawm ATP los ntawm ADP). Thaum lub zog siv zog thiab lub cev xav tau lub zog nce ntxiv, ATP rov ua haujlwm feem ntau tshwm sim los ntawm glycolytic thiab phosphagenic systems. Qhov no ua rau muaj kev tso tawm ntau ntxiv ntawm protons thiab, raws li qhov tshwm sim, acidosis.

Nyob rau hauv cov xwm txheej no, lactate ntau lawm los tiv thaiv lub cev los ntawm pyruvate tsub zuj zuj thiab cov khoom ntawm NAD + xav tau rau theem ob ntawm glycolysis. Robbergs qhia tias lactate pab tiv thaiv acidosis vim tias nws tuaj yeem nqa hydrogen ions tawm ntawm lub cell. Yog li, yog tias tsis muaj kev tsim cov lactate ntau ntxiv, acidosis thiab leeg nqaij qaug zog yuav tshwm sim sai dua.

Lactate tsis yog liam rau cov leeg nqaij qaug zog thaum lub sijhawm ua haujlwm hnyav. Kev qaug zog ua rau acidosis - kev txuam nrog hydrogen ions thiab hloov pauv hauv pH ntawm lub cev mus rau sab acidic. Lactate, ntawm qhov tod tes, tuaj yeem pab tiv thaiv acidosis.

Yuav ua li cas lactate zoo rau kev noj qab haus huv thiab qoj ib ce

Lactate yog ib qho khoom siv hluav taws xob

Nyob rau hauv lub 80s thiab 90s, George Brooks ua pov thawj Lactic Acid Tsis yog kis las tshuaj lom, tab sis ib tug zog Source - Yog hais tias koj paub siv nws, cov lactate kis los ntawm cov leeg hlwb mus rau hauv cov ntshav thiab thauj mus rau lub siab, qhov twg nws rov qab mus rau cov piam thaj. nyob rau hauv lub voj voog measles. Cov piam thaj yog tom qab ntawd thauj dua los ntawm cov ntshav mus rau cov leeg ua haujlwm thiab tuaj yeem siv rau lub zog tsim khoom thiab khaws cia ua glycogen.

Dab tsi ntxiv, txawm tias cov leeg nqaij tuaj yeem siv lactate ua roj. Xyoo 1999, Brooks tau tshawb pom tias kev kawm ua siab ntev txo qis cov ntshav lactate txawm tias cov hlwb txuas ntxiv tsim cov nyiaj tib yam. Hauv xyoo 2000, nws pom tias cov neeg ncaws pob muaj zog tau nce lactate carrier molecules, uas sai sai txav lactate los ntawm cytoplasm ntawm cell mus rau mitochondria.

Hauv kev sim ntxiv, cov kws tshawb fawb pom tsis tau tsuas yog muaj cov khoom noj muaj protein ntau hauv mitochondria, tab sis kuj yog lactate enzyme dehydrogenase, uas ua rau kev hloov pauv ntawm lactate rau hauv lub zog.

Cov kws tshawb fawb tau xaus lus tias lactate raug thauj mus rau mitochondria thiab hlawv nrog rau kev koom tes ntawm oxygen rau lub zog tsim.

Lactate yog lub zog rau cov leeg. Hauv daim siab, nws raug txo kom qabzib, uas tom qab ntawd rov siv los ntawm cov leeg lossis khaws cia hauv lawv li glycogen. Tsis tas li ntawd, lactate tuaj yeem hlawv ncaj qha rau hauv cov leeg kom lub zog.

Lactate nce endurance

Lactate pab ua kom oxygen noj, uas kuj muaj txiaj ntsig zoo rau kev ua siab ntev. Ib txoj kev tshawb fawb xyoo 2006 tau pom tias lactate, tsis zoo li cov piam thaj, nce cov pa oxygen coj los ntawm mitochondria, uas tso cai rau lawv tsim kom muaj zog ntxiv.

Thiab nyob rau xyoo 2014, nws tau pom tias lactate txo cov lus teb rau kev ntxhov siab thiab ua rau cov noob qoob loo ntxiv rau kev tsim cov mitochondria tshiab.

Lactate nce cov pa oxygen uas koj haus kom koj lub cev tuaj yeem daws kev ntxhov siab ntev dua.

Lactate tiv thaiv lub hlwb

Lactate tiv thaiv excitotoxicity los ntawm L-glutamate. Qhov no yog ib qho mob pathological nyob rau hauv uas, vim muaj kev ua haujlwm ntau dhau ntawm cov neurons, lawv cov mitochondria thiab daim nyias nyias raug puas tsuaj thiab cov cell tuag. Excitotoxicity tuaj yeem ua rau ntau yam sclerosis, mob stroke, Alzheimer's kab mob, thiab lwm yam kab mob cuam tshuam nrog kev puas tsuaj rau cov paj hlwb.

Ib txoj kev tshawb fawb 2013 pom tias lactate tswj cov kev ua haujlwm neuronal, tiv thaiv lub hlwb los ntawm excitotoxicity.

Tsis tas li ntawd, lactate muab lub hlwb nrog lwm cov khoom noj thaum cov piam thaj tsis txaus. Nyob rau tib lub sijhawm xyoo 2013, cov kws tshawb fawb pom tau tias qhov nce me ntsis hauv lactate ncig tso cai rau lub hlwb ua haujlwm ib txwm nyob rau hauv cov mob hypoglycemic.

Dab tsi ntxiv, kev tshawb fawb xyoo 2011 pom tias cov piam thaj tsis txaus los muab lub zog thaum lub sijhawm ua haujlwm hnyav synapse, thiab lactate tuaj yeem yog lub zog zoo uas txhawb nqa thiab txhim kho lub hlwb metabolism.

Thaum kawg, ib txoj kev tshawb fawb 2014 pom tias lactate nce tus nqi ntawm norepinephrine, neurotransmitter uas xav tau los muab lub hlwb nrog ntshav thiab ua kom pom tseeb.

Lactate tiv thaiv lub hlwb los ntawm excitotoxicity, pab raws li lub zog ntawm lub zog thiab txhim kho concentration.

Lactate txhawb cov leeg nqaij

Lactate tsim cov mob zoo rau cov leeg nqaij. Ib txoj kev tshawb fawb xyoo 2015 tau pom tias caffeine thiab lactate supplementation ua rau cov nqaij ntshiv loj hlob txawm tias thaum lub sijhawm ua haujlwm qis los ntawm kev ua kom cov qia hlwb thiab cov cim anabolic: nce kev qhia ntawm myogenin thiab follistatin.

Thaum ntxov li 20 xyoo dhau los, cov kws tshawb fawb pom tias tom qab kev qhia txog lactate thiab kev tawm dag zog (ua luam dej) hauv cov txiv neej nas, tus nqi ntawm testosterone hauv cov ntshav plasma nce. Tsis tas li ntawd, tus nqi ntawm luteinizing hormone nce, uas kuj txhawb kev tso tawm ntawm testosterone. Thiab qhov no, nyob rau hauv lem, muaj txiaj ntsig zoo rau cov leeg nqaij.

Lactate nce qhov tso tawm ntawm cov tshuaj hormones xav tau rau cov leeg nqaij.

Yuav ua li cas kom cov lactate nce

1. Noj tej yam uas muaj carbohydrates ib teev ua ntej koj ua haujlwm: qab zib txiv hmab txiv ntoo, chocolate, cereals. Nco ntsoov, lactate yog tsim thaum cov piam thaj tawg.
2. Sim muab koj qhov zoo tshaj plaws. Piv txwv li, sim ua ib qho kev sib tw los yog kev qhia ua haujlwm siab (HIIT). Ua qhov kev tawm dag zog no ob zaug hauv ib lub lis piam ntxiv rau koj qhov kev ua si tsis tu ncua, thiab maj mam koj lub cev yuav ua rau cov kua mis ntau ntxiv rau kev ua kom muaj zog, cov leeg loj hlob thiab tiv thaiv lub hlwb.